Diseases Associated with Acetaldehyde Toxicity

General ALDH Review

Targeting aldehyde dehydrogenase 2: New therapeutic opportunities
Chen CH, Batista Ferriera JC, Gross ER, Mochly-Rosen D. Physiol Rev. 2014. 94: 1-34

Update on the aldehyde dehydrogenase gene (ALDH) superfamily
Jackson B, Brocker C, Thompson DC, Black W, Vasiliou K, Nebert D, Vasiliou V. Human Genomics. 2011. 5(4): 283-303.

Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant
Perez-Miller S, Younus H, Vanam R, Chen SH, Mochly-Rosen D, Hurley TD. Nat Struct Mol Biol. 2010 Feb;17(2):159-64. 

Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family
Vasiliou V, Nebert D. Human Genomics. 2005. 2(2): 138-143.

Fanconi Anemia

Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients.
Hira A, Yabe H, Yoshida K, Okuno Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Nakamura J, Kojima S, Ogawa S, Matsuo K, Takata M and Yabe M. Blood. 2013 Oct 31; 122 (18):3206-9.

Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function
Garaycoechea JI, Crossan GP, Langevin F, Daly M, Arends MJ, Patel KJ. Nature. 2012; 489(7417):571-5. PMID: 22922648

Stressed out: endogenous aldehydes damage hematopoietic stem cells
Parmar K and D'Andrea AD Cell Stem Cell 11 2012.

Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice
Langevin F, Crossan GP, Rosado IV, Arends MJ, Patel KJ. Nature. 2011; 475(7354):53-8. PMID: 21734703

Cancer

Genetic modulation of ADH1B and ALDH2 polymorphisms with regard to alcohol and tobacco consumption for younger aged esophageal squamous cell carcinoma diagnosis
Lee CH, Wu DC, Wu IC, Goan YG, Lee JM, Chou SH, Chan TF, Huang HL, Hung YH, Huang MC, Lai TC, Wang TN, Lan CC, Tsai S, Lin Wy, Wu MT. Int. J. Cancer. 2009; 125, 1134-1142.

The alcohol flushing response: an unrecognized risk factor for esophageal cancer from alcohol consumption
Brooks PJ, Enoch MA, Goldman D, Li TK, Yokoyama A., PLoS Med. 2009;6(3):e50. PMID: 19320537

Carcinogenicity of alcoholic beverages
Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, Bouvard V, Altieri A, Cogliano V; WHO International Agency for Research on Cancer Monograph Working Group. Lancet Oncol. 2007 Apr; 8(4):292-3 PMID:17431955

Acute Alcohol Toxicity

Putative role of brain acetaldehyde in ethanol addiction
Den XS, Deitrich RA. Curr Drug Abuse Rev. 2008; 1(1): 3-8.

Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily
Marchitti SA, Brocker C, Stagos D, and Vasiliou V. Expert Opin Drug Metab Toxicol. 2008 June PMC 2009 March 19

The role of acetaldehyde in the actions of alcohol (update 2000)
Eriksson CJ. Alcohol Clin Exp Res. 2001; 25(5 Suppl ISBRA):15S-32S. PMID:11391045

Alcohol Metabolism Deficiency (ALMD)

Pharmacokinetic and pharmacodynamics basis for overcoming acetaldehyde-induced adverse reaction in Asian alcoholics, heterozygous for the variant ALDH2*2 gene allele
Chen YC, Peng GS, Tsao TP, Wang MF, Lu RB, Yin SJ. Pharmacogenetics and Genomics 2009

Refined geographic distribution of the oriental ALDH2*504Lys (nee 487Lys) variant
Li H, Borinskaya S, Yoshimura K, Kal'ina N, Marusin A, Stepanov, VA, Qin Z, Khaliq S, Lee MY, Yang Y Mohyuddin A, Gurwitz D, Mehdi QS, Rogaev E, Jin L, Yankovsky NK, Kidd JR, Kidd KK. Annals of Human Genetics (2009) 73, 335-345.

Pain

Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain
Vanessa O. Zambelli, Eric R. Gross, Che-Hong Chen, Vanessa P. Gutierrez, Yara Cury, Daria Mochly-Rosen. Sci Transl Med 6, 251ra118 (2014)

References in additional indications available upon request